Our research focuses on the complex interactions between the intestinal tract and the microbiota in both health and disease. We seek to better understand how commensal and pathogenic microbes influence mucosal immunity and contribute to the onset and progression of inflammatory (e.g., Inflammatory bowel diseases, graft-versus-host disease) and malignant diseases (e.g., leukemia, colorectal cancer). By integrating basic and translational research, our aim is to deepen the clinical understanding of the microbiome and advance microbiome-based therapeutic strategies. To address these challenges, we utilize a range of molecular biology and microbiology techniques, in conjunction with preclinical and gnotobiotic models. Insights from patient cohorts are validated and mechanistically explored within these preclinical models.