Dept. of Medical Microbiology and Hospital Epidemiology
Max von Pettenkofer Institute
LMU Munich
Pettenkoferstr. 9a
80336 München
Salmonella enterica serovars: non-typhoidal such as Typhimurium, typhoidal such as Paratyphi A and Typhi, Enteropathogenic E. coli such as ETEC
Wet lab, host cell infection and immune responses, genetical and biochemical approaches, bacterial mutant phenotypes and screens, immunofluorescence microscopy, live cell imaging
The research group focuses on deciphering and understanding the molecular mechanisms underlying the pathogenicity of the gastrointestinal pathogen Salmonella enterica. Highly adapted to an intracellular lifestyle, both typhoidal and non-typhoidal Salmonella express and secrete various effector proteins and virulence factors only when located within a host cell. Of particular interest are effector proteins that manipulate and influence the intracellular fate of Salmonella, as well as cytotoxins and glycolytic enzymes concerning their secretion mechanisms, cellular export, and impacts on various target cells during Salmonella infection.