Dept. of Experimental Parasitology
LMU Munich
Biomedical Center Munich, Physiological Chemistry
Großhaderner Str. 9
82152 Planegg-Martinsried
Our research focus is on Trypanosoma brucei, but through collaborations we have generated NGS data from human cells, Trypanosoma cruzi, Leishmania major, Toxoplasma gondii, Plasmodium falciparum and Calicophoron daubneyi.
Combination of wet lab (molecular biology), systems biology (e.g. ATAC-seq, ribosome profiling, Hi-C, MicroC, ChiP-seq, single cell RNA-seq, perturb-seq) and field work (through collaborations in Uganda and Kenya)
Using the unicellular parasite Trypanosoma brucei as a model, we aim to elucidate the mechanisms that control cell-to-cell heterogeneity in a population of pathogens at different scales. We are interested in how differences in genome sequence, chromatin organization, and 3D genome architecture influence the expression of different surface antigens. A particular focus of our work is to understand how ncRNAs contribute to the organization of the 3D genome architecture and how RNA processing hotspots can serve as ‘post-transcriptional’ enhancers.